Immunomodulatory activity of shikimic acid and quercitin in comparison with oseltamivir (Tamiflu) in an “in vitro” model
Identifieur interne : 001E18 ( Main/Exploration ); précédent : 001E17; suivant : 001E19Immunomodulatory activity of shikimic acid and quercitin in comparison with oseltamivir (Tamiflu) in an “in vitro” model
Auteurs : A. A. E. Bertelli [Italie, Niger] ; C. Mannari [Italie] ; S. Santi [Italie] ; C. Filippi [Italie] ; M. Migliori [Italie] ; L. Giovannini [Italie]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2008-04.
Abstract
The risk of an avian influenza pandemic has put oseltamivir (Tamiflu®) in the spotlight and has given rise to rumors that shikimic acid (SK), which is used for the synthesis of Tamiflu®, possesses therapeutic activity. This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL‐6 and IL‐8 from peripheral blood mononuclear cells (PBMCs). The experiments were conducted comparing the properties of SK, both alone and in combination, with those of Tamiflu®. The incubation of PBMCs with 100 nM Tamiflu® or SK at two concentrations (10 nM; 100 nM) did not produce any change in IL‐6 and IL‐8 baseline levels (data expressed as incremental change vs. baseline). On the contrary, incubation with SK and QT at both concentrations (10 and 100 nM) produced a significant increase in the release of IL‐8 as compared to other groups (4.19 ± 0.82, SK‐QT 10 nM; 3.83 ± 1.17 SK‐QT 100 nM, P < 0.05 vs. baseline 1.00 ± 0.10, Tamiflu® 100 nM 1.35 ± 0.16, SK 10 nM 1.68 ± 0.15 and SK 100 nM 1.80 ± 0.48). The SK‐QT combination also proved to be effective in the upregulation of IL‐6 (3.08 ± 0.46, SK‐QT 10 nM; 3.60 ± 0.74 SK‐QT 100 nM, P < 0.05 vs. baseline 1.00 ± 0.26). According to these findings SK alone is not able to modulate innate immunity in antiviral terms. However, the data show that the SK + QT combination, even at low doses, may be effective for the modulation of innate immunity. J. Med. Virol. 80:741–745, 2008. © 2008 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.21072
Affiliations:
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A. E." last="Bertelli">A. A. E. Bertelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Human Morphology, University of Milan, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Niger</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr" wicri:curation="lc">Italie</country><wicri:regionArea>Correspondence address: Dipartimento di Morfologia Umana, Università degli Studi di Milano, Via Mangiagalli, 31, 20133 Milano</wicri:regionArea><wicri:noRegion>20133 Milano</wicri:noRegion></affiliation></author><author><name sortKey="Mannari, C" sort="Mannari, C" uniqKey="Mannari C" first="C." last="Mannari">C. 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Giovannini</name><affiliation wicri:level="4"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Neuroscience, Section of Pharmacology, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">80</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="741">741</biblScope><biblScope unit="page" to="745">745</biblScope><biblScope unit="page-count">5</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-04">2008-04</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The risk of an avian influenza pandemic has put oseltamivir (Tamiflu®) in the spotlight and has given rise to rumors that shikimic acid (SK), which is used for the synthesis of Tamiflu®, possesses therapeutic activity. This study was undertaken to determine whether SK, either alone or in combination with quercitin (QT) is able to modulate the release of IL‐6 and IL‐8 from peripheral blood mononuclear cells (PBMCs). The experiments were conducted comparing the properties of SK, both alone and in combination, with those of Tamiflu®. The incubation of PBMCs with 100 nM Tamiflu® or SK at two concentrations (10 nM; 100 nM) did not produce any change in IL‐6 and IL‐8 baseline levels (data expressed as incremental change vs. baseline). On the contrary, incubation with SK and QT at both concentrations (10 and 100 nM) produced a significant increase in the release of IL‐8 as compared to other groups (4.19 ± 0.82, SK‐QT 10 nM; 3.83 ± 1.17 SK‐QT 100 nM, P < 0.05 vs. baseline 1.00 ± 0.10, Tamiflu® 100 nM 1.35 ± 0.16, SK 10 nM 1.68 ± 0.15 and SK 100 nM 1.80 ± 0.48). The SK‐QT combination also proved to be effective in the upregulation of IL‐6 (3.08 ± 0.46, SK‐QT 10 nM; 3.60 ± 0.74 SK‐QT 100 nM, P < 0.05 vs. baseline 1.00 ± 0.26). According to these findings SK alone is not able to modulate innate immunity in antiviral terms. However, the data show that the SK + QT combination, even at low doses, may be effective for the modulation of innate immunity. J. Med. Virol. 80:741–745, 2008. © 2008 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Niger</li></country><region><li>Toscane</li></region><settlement><li>Pise</li></settlement><orgName><li>Université de Pise</li></orgName></list><tree><country name="Italie"><noRegion><name sortKey="Bertelli, A A E" sort="Bertelli, A A E" uniqKey="Bertelli A" first="A. A. E." last="Bertelli">A. A. E. Bertelli</name></noRegion><name sortKey="Bertelli, A A E" sort="Bertelli, A A E" uniqKey="Bertelli A" first="A. A. E." last="Bertelli">A. A. E. Bertelli</name><name sortKey="Filippi, C" sort="Filippi, C" uniqKey="Filippi C" first="C." last="Filippi">C. Filippi</name><name sortKey="Giovannini, L" sort="Giovannini, L" uniqKey="Giovannini L" first="L." last="Giovannini">L. Giovannini</name><name sortKey="Mannari, C" sort="Mannari, C" uniqKey="Mannari C" first="C." last="Mannari">C. Mannari</name><name sortKey="Migliori, M" sort="Migliori, M" uniqKey="Migliori M" first="M." last="Migliori">M. Migliori</name><name sortKey="Santi, S" sort="Santi, S" uniqKey="Santi S" first="S." last="Santi">S. Santi</name></country><country name="Niger"><noRegion><name sortKey="Bertelli, A A E" sort="Bertelli, A A E" uniqKey="Bertelli A" first="A. A. E." last="Bertelli">A. A. E. Bertelli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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